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Split hand sign is a classic clinical sign seen in Motor Neuron Disease (MND), especially Amyotrophic Lateral Sclerosis (ALS). 🔍 What is it? It refers to selective wasting and weakness of: Thenar muscles (Abductor Pollicis Brevis) First dorsal interosseous (FDI) With relative sparing of: Hypothenar muscles (especially Abductor Digiti Minimi) ➡️ This creates the appearance of the hand being “split” into wasted and preserved muscle groups. ✋ Muscles Involved Wasted Spared Thenar muscles Hypothena
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