Multiple system atrophy (MSA) is an adult-onset, rapidly progressive neurodegenerative disorder characterised by the aggregation of α-synuclein in oligodendroglial cytoplasmatic inclusions.1 ...

Could drugs like Mounjaro treat people with cannabis use disorder? They might. Preliminary research indicates they may stop ...

A Mayo Clinic-led study found that high-dose vitamin D supplementation in inflammatory bowel disease (IBD) patients with low vitamin D levels was associated with increased protective IgA tagging and ...

In October 2024, Calluna Pharma concluded the Phase I clinical study of its lead product, CAL101, for fibrotic and ...

A randomized controlled trial in a Turkish high school found that students using unrestricted generative AI for math practice scored significantly higher during assisted sessions but performed worse ...

The treatment landscape of generalised myasthenia gravis, a prototypic antibody-mediated disorder of the neuromuscular junction, has considerably evolved in the past 8 years.1 The approval of targeted ...

The incidence and prevalence of heart failure with preserved ejection fraction (HFpEF) is increasing, along with the aging population and the ongoing rise in risk factors such as hypertension, ...

Whole-blood transfusion has recently gained favor in the management of severe hemorrhage; however, data from large clinical trials evaluating its clinical effectiveness and safety are lacking. We ...

Aim To evaluate the effectiveness of atropine 0.01% in young premyopic and low-myopic children. Methods Children (5–9 years old) with premyopia (spherical equivalent refraction, SER+1.00 to −0.49D, n ...

Introduction While digital technologies can increase the availability and access to evidence-based interventions, little is known about how users engage with them and the mechanisms associated with ...

Researchers at The Hospital for Sick Children (SickKids), working with international collaborators and youth and family caregivers, have developed a child- and youth-centred global standard for ...

In the past two decades, impact evaluation has become an unavoidable topic in the social sector. Yet beyond the discourse on how to measure social impact lies a structural problem: We are not ...