a sequence of data. So, applying first-order differencing amounts to subtracting the value at the current step from the value at the next step (t_i+1 - t_i ).

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† For urbanization, AAMR 1999-2020. *P-value <0.05. This is an ASCO Meeting Abstract from the 2025 ASCO Annual Meeting I. This abstract does not include a full text component.