The Diels–Alder reaction has been widely used in synthetic organic chemistry since its discovery in 1928. The catalyst-free nature, functional group tolerance and high efficiency of the Diels–Alder ...
(+)-Pleuromutilin is a structurally intricate natural antibiotic featuring a densely functionalized 5/6/8 tricyclic core and eight contiguous stereocenters. Here, the authors report a bioinspired ...
A novel study uncovers how a subtle chemical tweak transforms the naturally occurring phytotoxin into a powerful molecular glue, 12-deoxyfusicoccin (12-dFC), that locks 14-3-3 proteins onto the ...
National Laboratory of Solid State Microstructures, College of Engineering and Applied Sciences and Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, ...
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