Cutaneous squamous-cell carcinoma (SCC) is primarily caused by oncogenesis mediated by ultraviolet radiation, and β-human papillomavirus (β-HPV) is believed to be a mere facilitator that is ...

Researchers have identified an unexpected mechanism that links age-related stress to the decline of blood-forming stem cells.

A study shows that high levels of negatively charged lipids can lock growth receptors into an overactive state, driving ...

T cell activation—the process by which these key immune defenders recognize threats and mobilize against them—depends on exquisitely timed molecular signals. Now researchers have captured one of the ...

A new review links three forces shaping osteoarthritis: mechanical stress, integrin signaling, and integrin endocytosis. The authors argue that integrin trafficking can reprogram where and how long ...

Deep in the lungs, resident memory B cells stand guard against influenza reinfection—but whether they remain there may depend ...

A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key ...

A signaling pathway best known for shaping the brain before birth also helps govern how adults learn, adapt, and persist in ...

A study reveals how MLKL drives stem cell aging by damaging mitochondria without causing cell death, reducing regenerative ...