Array technologies create an opportunity to identify diagnostic and prognostic markers, as well as drug targets, from clinical samples. We have developed a mid-density spotted oligonucleotide array ...

Phase I Study of Adoptive T-Cell Therapy Using Antigen-Specific CD8+ T Cells for the Treatment of Patients With Metastatic Melanoma Two hundred fifty-one neuroblastoma specimens were analyzed using a ...

Inflammatory bowel disease (IBD) is a progressive, recurrent gastrointestinal disorder influenced by genetic, immunoregulatory and environmental factors and often requiring surgery for treatment.

Phase I Clinical Trial of Oxaliplatin in Children and Adolescents With Refractory Solid Tumors Oligonucleotide array comparative genomic hybridization (aCGH) was performed on 42 microdissected ...

Therapeutic oligonucleotides act on different stages of pathological gene expression. Standard schematic of oligonucleotide activities in pathogenesis disease progression. Decoys bind to transcription ...

Less than two percent of the human genome codes for proteins, with the rest being noncoding and likely helping with gene regulation. Mutations in the noncoding genome often trigger trait changes that ...