Learn how small mutations in non-coding DNA can alter sex development in rodents.

Humans have about 3 billion DNA bases in their genetic makeup. However, most of it does not encode for protein.

Non-coding DNA variants contribute to acute lymphoblastic leukemia (ALL) chemotherapy resistance. St. Jude Children's Research Hospital scientists have identified specific DNA variants in the ...

Researchers have revealed that so-called ‘junk DNA’ contains powerful switches that help control brain cells linked to Alzheimer’s disease. When people picture DNA, they often imagine a set of genes ...

Scientists have found new genetic causes for diabetes in babies—in a part of the genome that has historically been overlooked ...

Remarkably, 98 percent of our DNA does not code for genes. Once considered “junk DNA,” it is now well appreciated that these ...

Noncoding elements in the genome, such as enhancers, silencers, and insulators, play important roles in gene expression and thus cellular behavior. Therefore, these elements may be of particular ...

The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a key player in understanding complex diseases. Following the landmark ...

Typically, female mouse embryos with two X chromosomes develop ovaries because a gene called Sox9 is suppressed. In male ...

The human genome contains about 20,000 protein-coding genes, but that only accounts for roughly two percent of the genome. For many years, it was easier for scientists to simply ignore all of that ...

(L to R) Co-first author Jackson Mobley, PhD, corresponding author Daniel Savic, PhD, and co-first author Kashi Raj Bhattarai, PhD, all of the St. Jude Department of Pharmacy and Pharmaceutical ...

Researchers at Bar-Ilan University have discovered that changing just one letter in DNA can completely alter sex development ...