DNA repair is essential for the maintenance of genomic stability and its failure can lead to human disease. Various DNA repair systems exist, such as base excision repair, nucleotide excision repair, ...

Researchers have revealed the structural mechanisms of a major DNA repair pathway in human cells. The research, published today as a Reviewed Preprint in eLife, is described by the editors as a ...

From proofreading polymerases to complex backup repair systems, DNA repair is a high-yield MCAT topic that bridges molecular biology and human health. Understanding the mechanisms that safeguard ...

Researchers have captured detailed structural images of a DNA repair process called single-strand annealing, identifying a previously unseen intermediate stage. The study, using a yeast protein ...

Unrepaired DNA-protein crosslinks (DPCs) – highly toxic tangles of protein and DNA – cause a process that leads to premature aging and embryonic lethality in mice. The findings reveal a previously ...

In this July 31, 2017 photo provided by Oregon Health & Science University, Shoukhrat Mitalipov, left, talks with research assistant Hayley Darby in the Mitalipov Lab at OHSU in Portland, Ore.

For decades, the dream of fixing harmful mutations in mitochondrial DNA felt out of reach. Scientists have long known these mutations cause serious diseases that pass down only through mothers. They ...

Everyday DNA mutations can help us understand immune function and aging—and even mitigate harm caused by some inherited ...

You can always be judged by your scars. This is the idea that sums up what researchers at Spanish National Cancer Research Centre (CNIO) claim is one of the new breakthroughs in basic and biomedical ...

Scientists at the University of Rochester have discovered that bowhead whales, Earth's longest-living mammals, carry a DNA ...