When it comes to identifying cancer-driving mutations, research has focused almost exclusively on understanding how mutations in the coding region of genes may alter a protein’s function to promote ...

Despite progress in defining functional elements of noncoding DNA, it is still not fully understood. Researchers, using an experiment that elucidated the function of tens of thousands of noncoding ...

Inocras and the Broad Institute analyzed 8,000+ TCGA cancer genomes to uncover new drivers and create a harmonized dataset ...

Humans have about 3 billion DNA bases in their genetic makeup. However, most of it does not encode for protein.

In a recent study published in Nature, researchers in the United States aggregated and processed 76,156 human genomes to construct a genomic constraint map named "genomic non-coding constraint of ...

Researchers at Uppsala University have developed a new method to identify conserved noncoding mutations in the genome that may play a driving role in medulloblastoma brain tumors in children. The ...

Learn how small mutations in non-coding DNA can alter sex development in rodents.