Health care is undergoing an important and well-needed shift from a one-size-fits-all approach to more personalized, precise, patient-focused care. A similar approach needs to be implemented at scale ...

How can you design and execute early phase trials to get the results needed with limited resources and time? We need to balance what we can do and the resources we have with what needs to be done for ...

Chronic, relapsing inflammatory dermatoses such as psoriasis, atopic dermatitis, vitiligo and hidradenitis suppurativa pose distinct development challenges that traditional clinical trial models were ...

The aim of this article was to design clinical trials that test treatments for clinical significance in individual patients. In a repeated measures design a scalar summary statistic describes the ...

Early implementation of real-time clinical trial data sharing aims to reduce delays in safety signal detection and regulatory ...

Phase III Precision Medicine Clinical Trial Designs That Integrate Treatment and Biomarker Evaluation. If you have the appropriate software installed, you can download article citation data to the ...

The Forum on Regenerative Medicine hosted its fourth public workshop with the goal of exploring the design complexities and ethical issues associated with clinical trials for gene-based therapies.

Clinical trials are notoriously expensive, time consuming, and risky. Failure comes at a very high cost (millions of dollars and months of development time wasted), yet studies show that the rate of ...

Clinical trials are facing new and evolving challenges as costs increase and approval timelines remain lengthy. Modernisation of processes and utilisation of novel technologies can help overcome such ...

Systematic Review of the Diagnosis and Management of Malignant Extradural Spinal Cord Compression: The Cancer Care Ontario Practice Guidelines Initiative‘s Neuro-Oncology Disease Site Group Current ...